STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pnap_1023PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein; KEGG: bur:Bcep18194_A5914 benzoylformate decarboxylase; Belongs to the TPP enzyme family. (529 aa)    
Predicted Functional Partners:
Pnap_1022
PFAM: aldehyde dehydrogenase; KEGG: bja:blr6417 vanillin: NAD oxidoreductase; Belongs to the aldehyde dehydrogenase family.
 
 0.958
Pnap_1718
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: pol:Bpro_2318 acetolactate synthase, small subunit.
 
 0.950
Pnap_1020
PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase; KEGG: bbr:BB1109 FMN-dependent dehydrogenase.
  
 
 0.949
Pnap_0610
PFAM: aldehyde dehydrogenase; KEGG: bte:BTH_I0706 aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family.
 
 0.916
Pnap_3835
PFAM: aldehyde dehydrogenase; KEGG: bte:BTH_I0706 aldehyde dehydrogenase family protein; Belongs to the aldehyde dehydrogenase family.
 
 0.916
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.799
ilvD
KEGG: pol:Bpro_2052 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
  
 0.732
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.654
Pnap_0939
TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: pol:Bpro_0904 para-aminobenzoate synthase, component I.
  
 
 0.641
Pnap_2310
TIGRFAM: homocitrate synthase; PFAM: pyruvate carboxyltransferase; KEGG: bxe:Bxe_B1438 putative homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.635
Your Current Organism:
Polaromonas naphthalenivorans
NCBI taxonomy Id: 365044
Other names: P. naphthalenivorans CJ2, Polaromonas naphthalenivorans CJ2, Polaromonas naphthalenivorans str. CJ2, Polaromonas naphthalenivorans strain CJ2
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