Pnap_1076 protein (Polaromonas naphthalenivorans)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Pnap_1075	Pnap_1076	Pnap_1075	Pnap_1076	PFAM: OmpA/MotB domain protein; 17 kDa surface antigen; KEGG: pol:Bpro_1591 OmpA/MotB.	PFAM: aldo/keto reductase; KEGG: pol:Bpro_1592 aldo/keto reductase.	0.522
Pnap_1075	Pnap_1077	Pnap_1075	Pnap_1077	PFAM: OmpA/MotB domain protein; 17 kDa surface antigen; KEGG: pol:Bpro_1591 OmpA/MotB.	TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: pol:Bpro_1593 hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.	0.478
Pnap_1075	plsY	Pnap_1075	Pnap_1078	PFAM: OmpA/MotB domain protein; 17 kDa surface antigen; KEGG: pol:Bpro_1591 OmpA/MotB.	Acyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.	0.435
Pnap_1076	Pnap_1075	Pnap_1076	Pnap_1075	PFAM: aldo/keto reductase; KEGG: pol:Bpro_1592 aldo/keto reductase.	PFAM: OmpA/MotB domain protein; 17 kDa surface antigen; KEGG: pol:Bpro_1591 OmpA/MotB.	0.522
Pnap_1076	Pnap_1077	Pnap_1076	Pnap_1077	PFAM: aldo/keto reductase; KEGG: pol:Bpro_1592 aldo/keto reductase.	TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: pol:Bpro_1593 hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.	0.770
Pnap_1076	plsY	Pnap_1076	Pnap_1078	PFAM: aldo/keto reductase; KEGG: pol:Bpro_1592 aldo/keto reductase.	Acyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.	0.684
Pnap_1077	Pnap_1075	Pnap_1077	Pnap_1075	TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: pol:Bpro_1593 hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.	PFAM: OmpA/MotB domain protein; 17 kDa surface antigen; KEGG: pol:Bpro_1591 OmpA/MotB.	0.478
Pnap_1077	Pnap_1076	Pnap_1077	Pnap_1076	TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: pol:Bpro_1593 hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.	PFAM: aldo/keto reductase; KEGG: pol:Bpro_1592 aldo/keto reductase.	0.770
Pnap_1077	plsY	Pnap_1077	Pnap_1078	TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: pol:Bpro_1593 hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.	Acyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.	0.751
plsY	Pnap_1075	Pnap_1078	Pnap_1075	Acyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.	PFAM: OmpA/MotB domain protein; 17 kDa surface antigen; KEGG: pol:Bpro_1591 OmpA/MotB.	0.435
plsY	Pnap_1076	Pnap_1078	Pnap_1076	Acyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.	PFAM: aldo/keto reductase; KEGG: pol:Bpro_1592 aldo/keto reductase.	0.684
plsY	Pnap_1077	Pnap_1078	Pnap_1077	Acyl-phosphate glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.	TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: pol:Bpro_1593 hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.	0.751

Network Stats

number of nodes:

number of edges:

average node degree:

avg. local clustering coefficient:

expected number of edges:

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000724

Double-strand break repair via homologous recombination

10 of 96

2.28

7.65

1.22e-18

GO:0031297

Replication fork processing

6 of 30

2.56

5.54

1.29e-11

GO:0006310

DNA recombination

11 of 334

1.78

4.77

1.11e-16

GO:0045003

Double-strand break repair via synthesis-dependent strand annealing

4 of 8

2.96

4.17

2.13e-08

GO:0006281

DNA repair

11 of 454

1.65

3.94

1.86e-15

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000400

Four-way junction DNA binding

4 of 13

2.75

3.73

1.13e-07

GO:0140097

Catalytic activity, acting on DNA

7 of 215

1.78

3.04

1.68e-08

GO:0009378

Four-way junction helicase activity

3 of 5

3.04

2.88e-06

GO:0043138

3-5 DNA helicase activity

3 of 12

2.66

2.61

1.48e-05

GO:0008094

ATP-dependent activity, acting on DNA

5 of 116

1.9

2.58

1.90e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000800

Lateral element

3 of 14

2.59

2.1

0.00013

GO:0000781

Chromosome, telomeric region

4 of 91

1.91

1.87

0.00013

GO:0000152

Nuclear ubiquitin ligase complex

3 of 44

2.1

1.7

0.00049

GO:0048476

Holliday junction resolvase complex

2 of 5

2.87

1.61

0.0012

GO:0005694

Chromosome

7 of 1075

1.08

1.03

0.00017

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23300655

(2012) RAD51 and breast cancer susceptibility: no evidence for rare variant association in the Breast Cancer Family Registry study.

6 of 8

3.14

6.55

8.45e-13

PMID:27037238

(2016) Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.

7 of 39

2.52

5.86

1.85e-12

PMID:28934497

(2017) Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans.

6 of 17

2.81

5.83

9.45e-12

PMID:20690856

(2010) Regulation of homologous recombination in eukaryotes.

6 of 25

2.64

5.38

4.13e-11

PMID:19173305

(2009) Hitting the bulls eye: novel directed cancer therapy through helicase-targeted synthetic lethality.

5 of 9

3.01

5.15

3.16e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9058

Fanconi anemia pathway, and HDR through Single Strand Annealing (SSA)

11 of 64

2.5

10.51

3.85e-24

CL:9062

Homologous DNA Pairing and Strand Exchange, and Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

9 of 27

2.79

10.32

3.01e-21

CL:9066

Mitotic DNA replication maintenance of fidelity, and BRCA1-BARD1 complex

4 of 6

3.09

4.56

4.49e-09

CL:9094

RecQ family helicase-topoisomerase III complex, and Removal of the Flap Intermediate from the C-strand

4 of 11

2.82

4.08

2.65e-08

CL:9148

Fanconi anaemia nuclear complex, and Crossover junction endodeoxyribonuclease activity

2 of 18

2.31

0.95

0.0177

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa03440

Homologous recombination

8 of 39

2.58

8.1

2.49e-17

cfa03460

Fanconi anemia pathway

8 of 45

2.51

7.88

3.50e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-5693568

Resolution of D-loop Structures through Holliday Junction Intermediates

8 of 29

2.7

8.47

1.47e-17

CFA-5693579

Homologous DNA Pairing and Strand Exchange

7 of 24

2.73

7.73

7.24e-16

CFA-5693567

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

9 of 101

2.21

6.78

8.73e-17

CFA-5693616

Presynaptic phase of homologous DNA pairing and strand exchange

6 of 21

2.72

6.52

2.56e-13

CFA-73894

DNA Repair

10 of 280

1.82

4.81

7.24e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000800

Lateral element

2 of 6

2.79

1.03

0.0138

GOCC:0000793

Condensed chromosome

3 of 110

1.7

0.93

0.0138

GOCC:0005694

Chromosome

5 of 646

1.15

0.73

0.0138

GOCC:0031981

Nuclear lumen

5 of 1088

0.93

0.5

0.0421

GOCC:0005634

Nucleus

9 of 3900

0.63

0.43

0.0138

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0233

DNA recombination

2 of 14

2.42

1.02

0.0133

KW-0234

DNA repair

2 of 36

2.01

0.75

0.0386

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16124

RecQ zinc-binding

2 of 4

2.96

1.13

0.0093

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00956

This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain PUBMED:16530788.

2 of 2

3.26

1.6

0.0013

SM00341

Helicase and RNase D C-terminal

2 of 3

3.09

1.6

0.0013

SM00891

ERCC4 domain

2 of 5

2.87

1.56

0.0015

SM00490

Helicase superfamily c-terminal domain

3 of 104

1.72

1.16

0.0042

SM00487

DEAD-like helicases superfamily

3 of 100

1.74

1.16

0.0042

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