Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
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experimentally determined
co-expression
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gene co-occurrence
gene fusions
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[Homology]
Score
hemECandidate Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (377 aa)    
Predicted Functional Partners:
hemC
Pre-uroporphyrinogen synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.986
hemF
Coprogen oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
 
 0.965
Rta_28670
Hydroxymethylbilane hydrolyase (cyclizing); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.940
Rta_26650
Uroporphyrinogen III methylase; Belongs to the precorrin methyltransferase family.
    
 0.937
Rta_28660
uroporphyrin-III C-methyltransferase (Urogen III methylase)-like protein.
    
 0.907
hemH
Heme synthetase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.895
hemB
Candidate Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.832
hemL
Candidate glutamate-1-semialdehyde 2,1-aminomutase (Glutamate-1-semialdehyde aminotransferase).
 
  
 0.708
hemA
Candidate glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.679
gltB
Candidate Ferredoxin-dependent glutamate synthase.
 
   
 0.622
Your Current Organism:
Ramlibacter tataouinensis
NCBI taxonomy Id: 365046
Other names: Acidivorax sp. TTB310, Acidovorax sp. TTB310, R. tataouinensis TTB310, Ramlibacter tataouinensis TTB310, Ramlibacter tataouinensis str. TTB310, Ramlibacter tataouinensis strain TTB310
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