| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rta_18700 | folD | Rta_18700 | Rta_18640 | Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.958 |
| Rta_18700 | gcvH | Rta_18700 | Rta_14670 | Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). | Candidate glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.986 |
| Rta_18700 | gcvP | Rta_18700 | Rta_14660 | Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.981 |
| Rta_18700 | gcvT | Rta_18700 | Rta_14680 | Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). | Candidate aminomethyltransferase (Glycine cleavage system T protein). | 0.980 |
| Rta_18700 | glyA | Rta_18700 | Rta_15320 | Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). | Candidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.961 |
| Rta_18700 | lpd | Rta_18700 | Rta_10510 | Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). | Dihydrolipoamide dehydrogenase. | 0.976 |
| Rta_18700 | metF | Rta_18700 | Rta_06930 | Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). | Candidate 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.934 |
| Rta_18700 | thyA | Rta_18700 | Rta_14490 | Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). | Candidate thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.919 |
| folD | Rta_18700 | Rta_18640 | Rta_18700 | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). | 0.958 |
| folD | gcvH | Rta_18640 | Rta_14670 | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Candidate glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.957 |
| folD | gcvP | Rta_18640 | Rta_14660 | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.976 |
| folD | gcvT | Rta_18640 | Rta_14680 | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Candidate aminomethyltransferase (Glycine cleavage system T protein). | 0.963 |
| folD | glyA | Rta_18640 | Rta_15320 | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Candidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.983 |
| folD | lpd | Rta_18640 | Rta_10510 | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Dihydrolipoamide dehydrogenase. | 0.911 |
| folD | metF | Rta_18640 | Rta_06930 | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Candidate 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.937 |
| folD | thyA | Rta_18640 | Rta_14490 | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Candidate thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.946 |
| gcvH | Rta_18700 | Rta_14670 | Rta_18700 | Candidate glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Candidate dihydrolipoyl dehydrogenase (Dihydrolipoamide dehydrogenase). | 0.986 |
| gcvH | folD | Rta_14670 | Rta_18640 | Candidate glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Candidate bifunctional protein : methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.957 |
| gcvH | gcvP | Rta_14670 | Rta_14660 | Candidate glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P-protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| gcvH | gcvT | Rta_14670 | Rta_14680 | Candidate glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Candidate aminomethyltransferase (Glycine cleavage system T protein). | 0.999 |
