Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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metKCandidate S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa)    
Predicted Functional Partners:
metE
Candidate Methylcobalamin:homocysteine methyltransferase (Methionine synthase).
  
 0.963
metH
Candidate Methionine synthase.
  
 
 0.936
metH-2
Candidate methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.933
Rta_37780
S-adenosylmethionine decarboxylase-like protein; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
    
 0.933
Rta_14560
Candidate O-acetylhomoserine (Thiol)-lyase (O-acetylhomoserine sulfhydrylase); (Homocysteine synthase) (Methionine synthase).
  
 
 0.917
ribH
Candidate riboflavin synthase, beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
 
 0.916
aspC
Aspartate transaminase.
   
 
 0.913
ahcY
Candidate Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
 
 
 0.850
Rta_24930
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (Cobalamin-independent methionine synthase)-like protein.
  
 0.816
metF
Candidate 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
  
 0.808
Your Current Organism:
Ramlibacter tataouinensis
NCBI taxonomy Id: 365046
Other names: Acidivorax sp. TTB310, Acidovorax sp. TTB310, R. tataouinensis TTB310, Ramlibacter tataouinensis TTB310, Ramlibacter tataouinensis str. TTB310, Ramlibacter tataouinensis strain TTB310
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