| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rta_08200 | hisG | Rta_08200 | Rta_08220 | Conserved hypothetical protein; Belongs to the BolA/IbaG family. | Candidate ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.847 |
| Rta_08200 | murA | Rta_08200 | Rta_08210 | Conserved hypothetical protein; Belongs to the BolA/IbaG family. | Candidate UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.873 |
| Rta_37790 | murA | Rta_37790 | Rta_08210 | Nucleotidyltransferases-like protein. | Candidate UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.823 |
| Rta_37790 | murB | Rta_37790 | Rta_10580 | Nucleotidyltransferases-like protein. | Candidate UDP-N-acetylenolpyruvoylglucosamine reductase (UDP-N-acetylmuramate dehydrogenase); Cell wall formation. | 0.906 |
| Rta_37790 | rmlA1 | Rta_37790 | Rta_08700 | Nucleotidyltransferases-like protein. | dTDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. | 0.484 |
| galU | glgC | Rta_31460 | Rta_24830 | Candidate UTP--glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase); (Alpha-D-glucosyl-1-phosphate uridylyltransferase) (Uridine diphosphoglucose pyrophosphorylase). | Candidate glucose-1-phosphate cytidylyltransferase (CDP-glucose pyrophosphorylase). | 0.913 |
| galU | glmU | Rta_31460 | Rta_07530 | Candidate UTP--glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase); (Alpha-D-glucosyl-1-phosphate uridylyltransferase) (Uridine diphosphoglucose pyrophosphorylase). | Candidate Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.917 |
| galU | murA | Rta_31460 | Rta_08210 | Candidate UTP--glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase); (Alpha-D-glucosyl-1-phosphate uridylyltransferase) (Uridine diphosphoglucose pyrophosphorylase). | Candidate UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.874 |
| galU | rmlA1 | Rta_31460 | Rta_08700 | Candidate UTP--glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase); (Alpha-D-glucosyl-1-phosphate uridylyltransferase) (Uridine diphosphoglucose pyrophosphorylase). | dTDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. | 0.928 |
| glgC | galU | Rta_24830 | Rta_31460 | Candidate glucose-1-phosphate cytidylyltransferase (CDP-glucose pyrophosphorylase). | Candidate UTP--glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase); (Alpha-D-glucosyl-1-phosphate uridylyltransferase) (Uridine diphosphoglucose pyrophosphorylase). | 0.913 |
| glgC | glmU | Rta_24830 | Rta_07530 | Candidate glucose-1-phosphate cytidylyltransferase (CDP-glucose pyrophosphorylase). | Candidate Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.831 |
| glgC | murA | Rta_24830 | Rta_08210 | Candidate glucose-1-phosphate cytidylyltransferase (CDP-glucose pyrophosphorylase). | Candidate UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.817 |
| glgC | rmlA1 | Rta_24830 | Rta_08700 | Candidate glucose-1-phosphate cytidylyltransferase (CDP-glucose pyrophosphorylase). | dTDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. | 0.947 |
| glmU | galU | Rta_07530 | Rta_31460 | Candidate Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Candidate UTP--glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase); (Alpha-D-glucosyl-1-phosphate uridylyltransferase) (Uridine diphosphoglucose pyrophosphorylase). | 0.917 |
| glmU | glgC | Rta_07530 | Rta_24830 | Candidate Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Candidate glucose-1-phosphate cytidylyltransferase (CDP-glucose pyrophosphorylase). | 0.831 |
| glmU | lpxA | Rta_07530 | Rta_17550 | Candidate Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Candidate Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.865 |
| glmU | murA | Rta_07530 | Rta_08210 | Candidate Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Candidate UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.953 |
| glmU | murC | Rta_07530 | Rta_09710 | Candidate Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Candidate UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.569 |
| glmU | rmlA1 | Rta_07530 | Rta_08700 | Candidate Bifunctional glmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | dTDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. | 0.857 |
| hisG | Rta_08200 | Rta_08220 | Rta_08200 | Candidate ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | Conserved hypothetical protein; Belongs to the BolA/IbaG family. | 0.847 |
