| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rta_14460 | Rta_14500 | Rta_14460 | Rta_14500 | Conserved hypothetical protein. | D-lactate dehydrogenase (cytochrome)-like protein. | 0.424 |
| Rta_14460 | Rta_14510 | Rta_14460 | Rta_14510 | Conserved hypothetical protein. | Candidate membrane protein. | 0.424 |
| Rta_14460 | folA | Rta_14460 | Rta_14480 | Conserved hypothetical protein. | Candidate dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.516 |
| Rta_14460 | thyA | Rta_14460 | Rta_14490 | Conserved hypothetical protein. | Candidate thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.516 |
| Rta_14460 | xthA | Rta_14460 | Rta_14470 | Conserved hypothetical protein. | Candidate exodeoxyribonuclease III. | 0.516 |
| Rta_14500 | Rta_14460 | Rta_14500 | Rta_14460 | D-lactate dehydrogenase (cytochrome)-like protein. | Conserved hypothetical protein. | 0.424 |
| Rta_14500 | Rta_14510 | Rta_14500 | Rta_14510 | D-lactate dehydrogenase (cytochrome)-like protein. | Candidate membrane protein. | 0.835 |
| Rta_14500 | Rta_14520 | Rta_14500 | Rta_14520 | D-lactate dehydrogenase (cytochrome)-like protein. | Candidate membrane protein. | 0.608 |
| Rta_14500 | Rta_25180 | Rta_14500 | Rta_25180 | D-lactate dehydrogenase (cytochrome)-like protein. | Candidate electron transfer flavoprotein alpha-subunit (Electron transfer flavoprotein large subunit). | 0.672 |
| Rta_14500 | Rta_25190 | Rta_14500 | Rta_25190 | D-lactate dehydrogenase (cytochrome)-like protein. | Candidate electron transfer flavoprotein beta-subunit (Electron transfer flavoprotein small subunit). | 0.580 |
| Rta_14500 | Rta_30600 | Rta_14500 | Rta_30600 | D-lactate dehydrogenase (cytochrome)-like protein. | Formate dehydrogenase beta subunit; NADH:ubiquinone oxidoreductase subunit 2 or 24 kDa subunit and subunit 1 or 51 kDa subunit fusion, chain E and chain F fusion-like protein. | 0.558 |
| Rta_14500 | ctaC-2 | Rta_14500 | Rta_33760 | D-lactate dehydrogenase (cytochrome)-like protein. | Candidate cytochrome c oxidase polypeptide II precursor (Cytochrome aa3 subunit 2); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | 0.518 |
| Rta_14500 | folA | Rta_14500 | Rta_14480 | D-lactate dehydrogenase (cytochrome)-like protein. | Candidate dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.628 |
| Rta_14500 | thyA | Rta_14500 | Rta_14490 | D-lactate dehydrogenase (cytochrome)-like protein. | Candidate thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.637 |
| Rta_14500 | xthA | Rta_14500 | Rta_14470 | D-lactate dehydrogenase (cytochrome)-like protein. | Candidate exodeoxyribonuclease III. | 0.624 |
| Rta_14510 | Rta_14460 | Rta_14510 | Rta_14460 | Candidate membrane protein. | Conserved hypothetical protein. | 0.424 |
| Rta_14510 | Rta_14500 | Rta_14510 | Rta_14500 | Candidate membrane protein. | D-lactate dehydrogenase (cytochrome)-like protein. | 0.835 |
| Rta_14510 | Rta_14520 | Rta_14510 | Rta_14520 | Candidate membrane protein. | Candidate membrane protein. | 0.637 |
| Rta_14510 | folA | Rta_14510 | Rta_14480 | Candidate membrane protein. | Candidate dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.644 |
| Rta_14510 | thyA | Rta_14510 | Rta_14490 | Candidate membrane protein. | Candidate thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.642 |