| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rta_21145 | Rta_35070 | Rta_21145 | Rta_35070 | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Conserved hypothetical protein. | 0.900 |
| Rta_21145 | ndk | Rta_21145 | Rta_18900 | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Candidate nucleoside diphosphate kinase (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.903 |
| Rta_21145 | pyrF | Rta_21145 | Rta_01990 | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Candidate Orotidine 5 -phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.900 |
| Rta_21145 | pyrG | Rta_21145 | Rta_25790 | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Candidate CTP synthase (UTP--ammonia ligase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.906 |
| Rta_21145 | pyrH | Rta_21145 | Rta_17450 | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Uridylate kinase (Uridine monophosphate kinase)-like protein; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.900 |
| Rta_21145 | pyrR | Rta_21145 | Rta_34090 | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Candidate bifunctional protein : Pyrimidine operon attenuation regulatory protein; Uracil phosphoribosyltransferase. | 0.902 |
| Rta_21145 | surE | Rta_21145 | Rta_24430 | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Candidate acid phosphatase (Stationary-phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| Rta_21145 | thyA | Rta_21145 | Rta_14490 | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Candidate thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
| Rta_21145 | tmk | Rta_21145 | Rta_19840 | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Candidate thymidylate kinase (dTMP kinase); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.903 |
| Rta_21145 | upp | Rta_21145 | Rta_21250 | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Candidate uracil phosphoribosyltransferase (UMP pyrophosphorylase); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.924 |
| Rta_35070 | Rta_21145 | Rta_35070 | Rta_21145 | Conserved hypothetical protein. | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.900 |
| Rta_35070 | pyrF | Rta_35070 | Rta_01990 | Conserved hypothetical protein. | Candidate Orotidine 5 -phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.900 |
| Rta_35070 | pyrH | Rta_35070 | Rta_17450 | Conserved hypothetical protein. | Uridylate kinase (Uridine monophosphate kinase)-like protein; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.900 |
| Rta_35070 | pyrR | Rta_35070 | Rta_34090 | Conserved hypothetical protein. | Candidate bifunctional protein : Pyrimidine operon attenuation regulatory protein; Uracil phosphoribosyltransferase. | 0.900 |
| Rta_35070 | surE | Rta_35070 | Rta_24430 | Conserved hypothetical protein. | Candidate acid phosphatase (Stationary-phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| Rta_35070 | thyA | Rta_35070 | Rta_14490 | Conserved hypothetical protein. | Candidate thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
| Rta_35070 | tmk | Rta_35070 | Rta_19840 | Conserved hypothetical protein. | Candidate thymidylate kinase (dTMP kinase); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
| Rta_35070 | upp | Rta_35070 | Rta_21250 | Conserved hypothetical protein. | Candidate uracil phosphoribosyltransferase (UMP pyrophosphorylase); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.900 |
| ndk | Rta_21145 | Rta_18900 | Rta_21145 | Candidate nucleoside diphosphate kinase (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Candidate septum formation protein Maf; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.903 |
| ndk | pyrG | Rta_18900 | Rta_25790 | Candidate nucleoside diphosphate kinase (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Candidate CTP synthase (UTP--ammonia ligase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.943 |