Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ilvCAlpha-keto-beta-hydroxylacil reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)    
Predicted Functional Partners:
ilvH
Candidate acetolactate synthase small subunit (Acetohydroxy-acid synthase small subunit).
 
 
 0.999
ilvI
Candidate acetolactate synthase large subunit (Acetohydroxy-acid synthase large subunit).
 
 
 0.994
ilvD
Candidate Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.984
Rta_14300
Acetolactate synthase large subunit (Acetohydroxy-acid synthase large subunit)-like protein; Belongs to the TPP enzyme family.
 
 
 0.982
ilvD-3
Candidate dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.980
Rta_23720
Acetolactate synthase large subunit (Acetohydroxy-acid synthase large subunit)-like protein; Belongs to the TPP enzyme family.
 
 
 0.974
Rta_16710
Acetohydroxy-acid synthase small subunit; Belongs to the TPP enzyme family.
  
 
 0.962
leuC-5
Alpha-IPM isomerase.
 
  
 0.778
gltB
Candidate Ferredoxin-dependent glutamate synthase.
  
  
 0.775
leuC-2
Alpha-IPM isomerase.
 
  
 0.774
Your Current Organism:
Ramlibacter tataouinensis
NCBI taxonomy Id: 365046
Other names: Acidivorax sp. TTB310, Acidovorax sp. TTB310, R. tataouinensis TTB310, Ramlibacter tataouinensis TTB310, Ramlibacter tataouinensis str. TTB310, Ramlibacter tataouinensis strain TTB310
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