| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rta_15710 | ribE | Rta_15710 | Rta_15220 | Hydrolases (HAD superfamily)-like protein. | Candidate riboflavin synthase, alpha chain. | 0.901 |
| Rta_15710 | ribF | Rta_15710 | Rta_31780 | Hydrolases (HAD superfamily)-like protein. | Candidate bifunctional riboflavin biosynthesis protein : Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase); Belongs to the ribF family. | 0.915 |
| Rta_31770 | lspA | Rta_31770 | Rta_31800 | Conserved hypothetical protein. | Signal peptidase II; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.437 |
| Rta_31770 | ribF | Rta_31770 | Rta_31780 | Conserved hypothetical protein. | Candidate bifunctional riboflavin biosynthesis protein : Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase); Belongs to the ribF family. | 0.681 |
| coaBC | coaD | Rta_25780 | Rta_33470 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Dephospho-CoA pyrophosphorylase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.947 |
| coaBC | gmk | Rta_25780 | Rta_32980 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Candidate guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | 0.441 |
| coaBC | ribF | Rta_25780 | Rta_31780 | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Candidate bifunctional riboflavin biosynthesis protein : Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase); Belongs to the ribF family. | 0.703 |
| coaD | coaBC | Rta_33470 | Rta_25780 | Dephospho-CoA pyrophosphorylase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.947 |
| coaD | folC | Rta_33470 | Rta_10660 | Dephospho-CoA pyrophosphorylase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Tetrahydrofolylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.542 |
| coaD | gmk | Rta_33470 | Rta_32980 | Dephospho-CoA pyrophosphorylase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Candidate guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | 0.507 |
| coaD | ribF | Rta_33470 | Rta_31780 | Dephospho-CoA pyrophosphorylase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Candidate bifunctional riboflavin biosynthesis protein : Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase); Belongs to the ribF family. | 0.674 |
| folC | coaD | Rta_10660 | Rta_33470 | Tetrahydrofolylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dephospho-CoA pyrophosphorylase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.542 |
| folC | ribF | Rta_10660 | Rta_31780 | Tetrahydrofolylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Candidate bifunctional riboflavin biosynthesis protein : Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase); Belongs to the ribF family. | 0.647 |
| gmk | coaBC | Rta_32980 | Rta_25780 | Candidate guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.441 |
| gmk | coaD | Rta_32980 | Rta_33470 | Candidate guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Dephospho-CoA pyrophosphorylase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.507 |
| gmk | ribF | Rta_32980 | Rta_31780 | Candidate guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Candidate bifunctional riboflavin biosynthesis protein : Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase); Belongs to the ribF family. | 0.624 |
| gmk | truB | Rta_32980 | Rta_19610 | Candidate guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. | Uracil hydrolyase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.514 |
| lspA | Rta_31770 | Rta_31800 | Rta_31770 | Signal peptidase II; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Conserved hypothetical protein. | 0.437 |
| lspA | ribF | Rta_31800 | Rta_31780 | Signal peptidase II; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Candidate bifunctional riboflavin biosynthesis protein : Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase); Belongs to the ribF family. | 0.693 |
| murJ | ribF | Rta_27840 | Rta_31780 | Candidate virulence factor; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | Candidate bifunctional riboflavin biosynthesis protein : Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase); Belongs to the ribF family. | 0.776 |