Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gmkCandidate guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. (206 aa)    
Predicted Functional Partners:
guaA
Candidate GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
 
 0.960
relA-2
Candidate GTP pyrophosphokinase (GTP pyrophosphokinase); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.958
Rta_31420
Guanylate kinase (GMP kinase)-like protein.
  
  
 
0.921
ndk
Candidate nucleoside diphosphate kinase (Nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.918
purB
Candidate adenylosuccinate lyase (Adenylosuccinase); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
 0.918
surE
Candidate acid phosphatase (Stationary-phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
  
  
  0.916
guaC
Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
    
 0.913
nrdA
Candidate ribonucleoside-diphosphate reductase, alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
 0.911
nrdB
Candidate ribonucleoside reductase, beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
   
 
 0.907
Rta_35070
Conserved hypothetical protein.
     
  0.900
Your Current Organism:
Ramlibacter tataouinensis
NCBI taxonomy Id: 365046
Other names: Acidivorax sp. TTB310, Acidovorax sp. TTB310, R. tataouinensis TTB310, Ramlibacter tataouinensis TTB310, Ramlibacter tataouinensis str. TTB310, Ramlibacter tataouinensis strain TTB310
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