| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rta_15910 | ilvA | Rta_15910 | Rta_35300 | 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase)-like protein. | Candidate threonine dehydratase biosynthetic (Threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.920 |
| Rta_15910 | leuB | Rta_15910 | Rta_28170 | 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase)-like protein. | Candidate 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.917 |
| Rta_16260 | Rta_17240 | Rta_16260 | Rta_17240 | Candidate serine--glyoxylate aminotransferase (Serine--glyoxylate transaminase). | Candidate phosphoserine phosphatase (O-phosphoserine phosphohydrolase). | 0.914 |
| Rta_16260 | glyA | Rta_16260 | Rta_15320 | Candidate serine--glyoxylate aminotransferase (Serine--glyoxylate transaminase). | Candidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
| Rta_16260 | ilvA | Rta_16260 | Rta_35300 | Candidate serine--glyoxylate aminotransferase (Serine--glyoxylate transaminase). | Candidate threonine dehydratase biosynthetic (Threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.909 |
| Rta_16260 | ltaE | Rta_16260 | Rta_35820 | Candidate serine--glyoxylate aminotransferase (Serine--glyoxylate transaminase). | Candidate low-specificity L-threonine aldolase. | 0.909 |
| Rta_16260 | pssA | Rta_16260 | Rta_17180 | Candidate serine--glyoxylate aminotransferase (Serine--glyoxylate transaminase). | Candidate Phosphatidylserine synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| Rta_16260 | trpA | Rta_16260 | Rta_28230 | Candidate serine--glyoxylate aminotransferase (Serine--glyoxylate transaminase). | Candidate tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.912 |
| Rta_16260 | trpB | Rta_16260 | Rta_28220 | Candidate serine--glyoxylate aminotransferase (Serine--glyoxylate transaminase). | Candidate tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.907 |
| Rta_17240 | Rta_16260 | Rta_17240 | Rta_16260 | Candidate phosphoserine phosphatase (O-phosphoserine phosphohydrolase). | Candidate serine--glyoxylate aminotransferase (Serine--glyoxylate transaminase). | 0.914 |
| Rta_17240 | glyA | Rta_17240 | Rta_15320 | Candidate phosphoserine phosphatase (O-phosphoserine phosphohydrolase). | Candidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
| Rta_17240 | ilvA | Rta_17240 | Rta_35300 | Candidate phosphoserine phosphatase (O-phosphoserine phosphohydrolase). | Candidate threonine dehydratase biosynthetic (Threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.904 |
| Rta_17240 | pssA | Rta_17240 | Rta_17180 | Candidate phosphoserine phosphatase (O-phosphoserine phosphohydrolase). | Candidate Phosphatidylserine synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.902 |
| Rta_17240 | trpA | Rta_17240 | Rta_28230 | Candidate phosphoserine phosphatase (O-phosphoserine phosphohydrolase). | Candidate tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.904 |
| Rta_17240 | trpB | Rta_17240 | Rta_28220 | Candidate phosphoserine phosphatase (O-phosphoserine phosphohydrolase). | Candidate tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.920 |
| glyA | Rta_16260 | Rta_15320 | Rta_16260 | Candidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Candidate serine--glyoxylate aminotransferase (Serine--glyoxylate transaminase). | 0.920 |
| glyA | Rta_17240 | Rta_15320 | Rta_17240 | Candidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Candidate phosphoserine phosphatase (O-phosphoserine phosphohydrolase). | 0.926 |
| glyA | ilvA | Rta_15320 | Rta_35300 | Candidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Candidate threonine dehydratase biosynthetic (Threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.933 |
| glyA | ltaE | Rta_15320 | Rta_35820 | Candidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Candidate low-specificity L-threonine aldolase. | 0.943 |
| glyA | pssA | Rta_15320 | Rta_17180 | Candidate serine hydroxymethyltransferase (Serine methylase); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Candidate Phosphatidylserine synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
