node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SIQ58867.1 | apt | SAMN05421840_102256 | SAMN05421840_105235 | Glutamate synthase (NADPH) large subunit. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.415 |
SIQ58867.1 | hisA | SAMN05421840_102256 | SAMN05421840_1239 | Glutamate synthase (NADPH) large subunit. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.447 |
SIQ58867.1 | hisB | SAMN05421840_102256 | SAMN05421840_1237 | Glutamate synthase (NADPH) large subunit. | Imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.852 |
SIQ58867.1 | hisD | SAMN05421840_102256 | SAMN05421840_1235 | Glutamate synthase (NADPH) large subunit. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.571 |
SIQ58867.1 | hisF | SAMN05421840_102256 | SAMN05421840_12310 | Glutamate synthase (NADPH) large subunit. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.945 |
SIQ58867.1 | hisH | SAMN05421840_102256 | SAMN05421840_1238 | Glutamate synthase (NADPH) large subunit. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.934 |
SIQ58867.1 | hisI | SAMN05421840_102256 | SAMN05421840_12311 | Glutamate synthase (NADPH) large subunit. | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.912 |
SIQ58867.1 | purH | SAMN05421840_102256 | SAMN05421840_107189 | Glutamate synthase (NADPH) large subunit. | IMP cyclohydrolase. | 0.933 |
apt | SIQ58867.1 | SAMN05421840_105235 | SAMN05421840_102256 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Glutamate synthase (NADPH) large subunit. | 0.415 |
apt | hisF | SAMN05421840_105235 | SAMN05421840_12310 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.936 |
apt | hisG | SAMN05421840_105235 | SAMN05421840_1234 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.434 |
apt | hisH | SAMN05421840_105235 | SAMN05421840_1238 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.919 |
apt | hisI | SAMN05421840_105235 | SAMN05421840_12311 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.839 |
apt | purH | SAMN05421840_105235 | SAMN05421840_107189 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | IMP cyclohydrolase. | 0.980 |
hisA | SIQ58867.1 | SAMN05421840_1239 | SAMN05421840_102256 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Glutamate synthase (NADPH) large subunit. | 0.447 |
hisA | hisB | SAMN05421840_1239 | SAMN05421840_1237 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.999 |
hisA | hisC | SAMN05421840_1239 | SAMN05421840_1236 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.989 |
hisA | hisD | SAMN05421840_1239 | SAMN05421840_1235 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.994 |
hisA | hisF | SAMN05421840_1239 | SAMN05421840_12310 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | SAMN05421840_1239 | SAMN05421840_1234 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.994 |