Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_0047Conserved hypothetical protein. (291 aa)    
Predicted Functional Partners:
zmpB
Zinc metalloprotease; LPXTG motif.
  
     0.764
licB
Choline transport protein.
  
     0.735
smi_1306
Surface anchored protein; LPXTG motif.
  
     0.707
pce2
Teichoic acid phosphorylcholine esterase/choline binding protein E, Pce2, truncation; COG2333, ComEC, predicted hydrolase (metallo-beta-lactamase superfamily).
  
    0.662
smi_0398
ABC transporter permease protein; COG0577.
  
     0.605
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
   0.591
smi_0386
Conserved hypothetical protein.
  
    0.538
smi_1060
Conserved hypothetical protein.
  
     0.534
smi_1089
Conserved hypothetical protein.
  
     0.526
polI
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
       0.525
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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