Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-expression
Experiments
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[Homology]
Score
smi_0058Histidine kinase; Pheromone receptor, comD-type. (448 aa)    
Predicted Functional Partners:
smi_0059
Response regulator of the LytR/AlgR family.
 
 
 0.995
comE
Response regulator; comE, competence-specific.
 
 
 0.982
comD
Histidine kinase; comD, competence-specific.
  
  
 
0.923
comC
Competence stimulating peptide (CSP) precursor; Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family.
     
  0.900
spiR2
Response regulator.
 
  
 0.827
CBJ21355.1
Excreted peptide; Bacteriocin/pheromone -type, double glycine-cleavage motif.
       0.661
smi_1094
Conserved hypothetical protein; COG2378, predicted transcriptional regulator.
  
     0.540
cbp12
Choline binding protein cbp12; COG5263, glucan-binding domain (YG repeat).
  
     0.505
cbp4
Choline binding protein Cbp4; COG5263, glucan-binding domain (YG repeat).
 
     0.500
cbp10
Choline binding protein Cbp10; COG5263, glucan binding domain (YG repeat).
  
     0.500
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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