Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_0181Conserved hypothetical protein. (67 aa)    
Predicted Functional Partners:
smi_0180
Site-specific recombinase, phage integrase family; Belongs to the 'phage' integrase family.
 
     0.895
smi_0182
Rep protein.
 
     0.795
smi_1341
Site-specific recombinase, phage integrase family; Cd01189, phiLC3 phage and phage-related integrases; Belongs to the 'phage' integrase family.
 
     0.774
smi_0179
Guanosine polyphosphate pyrophosphohydrolases/synthetases (COG0317).
       0.645
smi_1283
Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
       0.444
smi_0183
Serine/threonine protein phosphatase.
       0.440
smi_1324
Transcriptional regulator, Tn916; COG2946, phage replication protein, helix-turn-helix.
 
   
 0.424
smi_1793
Conserved hypothetical protein.
 
     0.423
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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