Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_0308Response regulator. (228 aa)    
Predicted Functional Partners:
smi_0309
Histidine kinase.
 
 0.991
smi_0093
Histidine kinase.
 
 
 0.826
ciaH
Sensor protein CiaH histidine kinase.
 
   0.789
smi_1176
Histidine kinase; COG5002, VicK, signal transduction histidine kinase.
 
 
 0.781
smi_0650
Histidine kinase.
 
 
 0.690
smi_1072
Histidine kinase; COG0642, signal transduction histidine kinase.
 
   0.670
smi_0305
ABC transporter, ATP-binding protein.
     
 0.629
smi_0306
ABC transporter, membrane protein.
       0.620
smi_0307
ABC transporter, membrane protein.
       0.618
vncS
Histidine kinase.
 
 
 0.483
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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