tlyC protein (Streptococcus mitis) - STRING interaction network

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tlyC

Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain. (443 aa)

Predicted Functional Partners:

guaA

0.607

endA

0.577

smi_1387

0.551

fruA

0.480

smi_0921

0.471

pflC

0.461

smi_0708

0.449

murA

0.442

smi_1806

0.433

topA

0.430

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
endA	murA	smi_0319	smi_0317	DNA-entry nuclease (competence-specific nuclease).	UDP-N-acetylglucosamine-1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.795
endA	tlyC	smi_0319	smi_0320	DNA-entry nuclease (competence-specific nuclease).	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	0.577
fruA	tlyC	smi_1357	smi_0320	PTS system, fructose specific IIBC component.	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	0.480
guaA	tlyC	smi_1342	smi_0320	GMP-synthase; Catalyzes the synthesis of GMP from XMP.	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	0.607
guaA	topA	smi_1342	smi_1222	GMP-synthase; Catalyzes the synthesis of GMP from XMP.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.543
murA	endA	smi_0317	smi_0319	UDP-N-acetylglucosamine-1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	DNA-entry nuclease (competence-specific nuclease).	0.795
murA	tlyC	smi_0317	smi_0320	UDP-N-acetylglucosamine-1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	0.442
pflC	tlyC	smi_0304	smi_0320	Pyruvate-formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	0.461
smi_0708	smi_1806	smi_0708	smi_1806	Conserved hypothetical protein.	Phosphatase; Pfam01569, PAP2 superfamily.	0.461
smi_0708	tlyC	smi_0708	smi_0320	Conserved hypothetical protein.	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	0.449
smi_0921	tlyC	smi_0921	smi_0320	Membrane protein; COG0628, PerM, predicted permease.	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	0.471
smi_1387	tlyC	smi_1387	smi_0320	hlyIII superfamily protein; COG1272.	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	0.551
smi_1806	smi_0708	smi_1806	smi_0708	Phosphatase; Pfam01569, PAP2 superfamily.	Conserved hypothetical protein.	0.461
smi_1806	tlyC	smi_1806	smi_0320	Phosphatase; Pfam01569, PAP2 superfamily.	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	0.433
tlyC	endA	smi_0320	smi_0319	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	DNA-entry nuclease (competence-specific nuclease).	0.577
tlyC	fruA	smi_0320	smi_1357	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	PTS system, fructose specific IIBC component.	0.480
tlyC	guaA	smi_0320	smi_1342	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	GMP-synthase; Catalyzes the synthesis of GMP from XMP.	0.607
tlyC	murA	smi_0320	smi_0317	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	UDP-N-acetylglucosamine-1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.	0.442
tlyC	pflC	smi_0320	smi_0304	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	Pyruvate-formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.	0.461
tlyC	smi_0708	smi_0320	smi_0708	Hemolysins and related proteins containing CBS domains [General function prediction only]; COG1253; Domain of unknown function DUF21. This transmembrane region has no known function. Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to a protein, which does not contain this domain.	Conserved hypothetical protein.	0.449

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