murI protein (Streptococcus mitis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

murI

Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis. (264 aa)

Predicted Functional Partners:

murD

0.986

smi_0333

0.985

glnA

0.873

scpA

0.869

xerD

0.868

smi_0334

0.865

smi_0335

0.865

rsuA2

0.839

scpB

0.838

gdhA

0.837

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
gdhA	glnA	smi_0814	smi_0349	COG0334, GdhA, glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Glutamine synthetase type 1.	0.977
gdhA	murI	smi_0814	smi_0332	COG0334, GdhA, glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	0.837
glnA	gdhA	smi_0349	smi_0814	Glutamine synthetase type 1.	COG0334, GdhA, glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.977
glnA	murI	smi_0349	smi_0332	Glutamine synthetase type 1.	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	0.873
murD	murI	smi_1449	smi_0332	MurD D-glutamic acid adding enzyme; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	0.986
murD	scpB	smi_1449	smi_0338	MurD D-glutamic acid adding enzyme; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.	Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.	0.504
murI	gdhA	smi_0332	smi_0814	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	COG0334, GdhA, glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.837
murI	glnA	smi_0332	smi_0349	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	Glutamine synthetase type 1.	0.873
murI	murD	smi_0332	smi_1449	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	MurD D-glutamic acid adding enzyme; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.	0.986
murI	rsuA2	smi_0332	smi_0339	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	Ribosomal small subunit pseudouridine synthase A; COG1187, 16S rRNA pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family.	0.839
murI	scpA	smi_0332	smi_0337	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.	0.869
murI	scpB	smi_0332	smi_0338	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.	0.838
murI	smi_0333	smi_0332	smi_0333	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.985
murI	smi_0334	smi_0332	smi_0334	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	Conserved hypothetical protein.	0.865
murI	smi_0335	smi_0332	smi_0335	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	Conserved hypothetical protein.	0.865
murI	xerD	smi_0332	smi_0336	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	Recombinase, site specific; Putative tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site. Belongs to the 'phage' integrase family. XerD-like subfamily.	0.868
rsuA2	murI	smi_0339	smi_0332	Ribosomal small subunit pseudouridine synthase A; COG1187, 16S rRNA pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family.	Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.	0.839
rsuA2	scpA	smi_0339	smi_0337	Ribosomal small subunit pseudouridine synthase A; COG1187, 16S rRNA pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family.	Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.	0.863
rsuA2	scpB	smi_0339	smi_0338	Ribosomal small subunit pseudouridine synthase A; COG1187, 16S rRNA pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family.	Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.	0.923
rsuA2	smi_0333	smi_0339	smi_0333	Ribosomal small subunit pseudouridine synthase A; COG1187, 16S rRNA pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family.	Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.835

page 1 of 4

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Co-occurrence

Textmining

Co-expression

© STRING Consortium 2026

Credits

Access

Info

About