Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
glnRTranscriptional repressor of the glutamine synthetase gene. (118 aa)    
Predicted Functional Partners:
glnA
Glutamine synthetase type 1.
 
 
 0.993
smi_0347
Conserved hypothetical protein.
       0.739
gdhA
COG0334, GdhA, glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
      
 0.595
codY
GTP-sensing transcriptional pleiotropic repressor; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
      
 0.562
ccpA
Catabolite control protein A.
      
 0.543
smi_0683
Ammonium transporter, Amp/Mep/NrgA family; Pfam00909.
     
 0.514
smi_0351
Conserved hypothetical protein.
       0.477
rpoD
DNA-dependent RNA Polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
 
 0.477
smi_0350
Transcriptional regulator.
     
 0.472
rpoB
DNA-dependent RNA Polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.451
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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