Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
spiR2Response regulator. (245 aa)    
Predicted Functional Partners:
spiH
Histidine kinase; Peptide pheromone receptor, ComD type.
 
 
 0.999
spiR1
Regulatory protein, single domain response regulator.
     
 0.932
smi_0058
Histidine kinase; Pheromone receptor, comD-type.
 
  
 0.827
comD
Histidine kinase; comD, competence-specific.
 
  
 0.812
smi_1177
COG0745, response regulator, OmpR family.
      
 0.646
smi_1094
Conserved hypothetical protein; COG2378, predicted transcriptional regulator.
  
     0.579
smi_0367
Hypothetical protein.
       0.552
comA
Transport ATP-binding protein ComA.
 
   
 0.551
pncO
Metal-dependent CAAX amino terminal membrane protease family protein; Pfam02517.
      
 0.522
smi_1741
Response regulator; COG2197.
      
 0.520
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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