| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IF2 | cotS | smi_0379 | smi_0373 | Translation initiation factor; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | Aminoglycoside phosphotransferase. | 0.642 |
| IF2 | nusA | smi_0379 | smi_0376 | Translation initiation factor; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | Transcription termination-antitermination factor; Participates in both transcription termination and antitermination. | 0.981 |
| IF2 | rimP | smi_0379 | smi_0375 | Translation initiation factor; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | Conserved hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. | 0.954 |
| IF2 | smi_0362 | smi_0379 | smi_0362 | Translation initiation factor; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | ABC transporter membrane-spanning permease. | 0.447 |
| IF2 | smi_0377 | smi_0379 | smi_0377 | Translation initiation factor; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | Nucleic-acid-binding protein implicated in transcription termination. | 0.987 |
| IF2 | smi_0378 | smi_0379 | smi_0378 | Translation initiation factor; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | L7A family ribosomal protein; Pfam01248. | 0.997 |
| IF2 | trmB | smi_0379 | smi_0374 | Translation initiation factor; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | 0.706 |
| MecA | cotS | smi_0772 | smi_0373 | MecA protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | Aminoglycoside phosphotransferase. | 0.606 |
| MecA | ezrA | smi_0772 | smi_0861 | MecA protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. | 0.759 |
| MecA | smi_0362 | smi_0772 | smi_0362 | MecA protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | ABC transporter membrane-spanning permease. | 0.746 |
| cotS | IF2 | smi_0373 | smi_0379 | Aminoglycoside phosphotransferase. | Translation initiation factor; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | 0.642 |
| cotS | MecA | smi_0373 | smi_0772 | Aminoglycoside phosphotransferase. | MecA protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | 0.606 |
| cotS | ezrA | smi_0373 | smi_0861 | Aminoglycoside phosphotransferase. | Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. | 0.546 |
| cotS | nusA | smi_0373 | smi_0376 | Aminoglycoside phosphotransferase. | Transcription termination-antitermination factor; Participates in both transcription termination and antitermination. | 0.668 |
| cotS | rimP | smi_0373 | smi_0375 | Aminoglycoside phosphotransferase. | Conserved hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. | 0.713 |
| cotS | smi_0362 | smi_0373 | smi_0362 | Aminoglycoside phosphotransferase. | ABC transporter membrane-spanning permease. | 0.554 |
| cotS | smi_0377 | smi_0373 | smi_0377 | Aminoglycoside phosphotransferase. | Nucleic-acid-binding protein implicated in transcription termination. | 0.651 |
| cotS | smi_0378 | smi_0373 | smi_0378 | Aminoglycoside phosphotransferase. | L7A family ribosomal protein; Pfam01248. | 0.651 |
| cotS | smi_0866 | smi_0373 | smi_0866 | Aminoglycoside phosphotransferase. | Conserved hypothetical protein. | 0.661 |
| cotS | trmB | smi_0373 | smi_0374 | Aminoglycoside phosphotransferase. | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. | 0.865 |