Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_0383Conserved hypothetical protein. (444 aa)    
Predicted Functional Partners:
smi_0382
Conserved hypothetical protein.
 
     0.967
smi_0384
Conserved hypothetical protein.
       0.859
smi_0385
Helicase; COG1204, superfamily II helicase.
       0.728
smi_0603
ABC transporter, sugar transporter, sugar binding lipoprotein-N-acetylneuraminate-binding protein.
   
    0.601
smi_1011
Conserved hypothetical protein.
       0.461
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
       0.461
ribF
Bifunctional riboflavin kinase/FMN adenylyltransferase; COG0196, FAD synthase; Belongs to the ribF family.
       0.461
spxA
Regulatory protein Spx; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily.
       0.455
smi_0729
Conserved hypothetical protein; Belongs to the UPF0223 family.
       0.446
smi_0730
Cd01637, IMPase_like, inositol-monophosphatase-like domains.
       0.446
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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