Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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smi_0405phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (208 aa)    
Predicted Functional Partners:
pheS
phenylalanyl-tRNA synthetase, alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
 
 
 0.915
smi_0403
Conserved hypothetical protein.
       0.843
smi_0404
Conserved hypothetical protein; COG0526: thiol-disulfide isomerase and thioredoxins.
       0.843
smi_0406
3-hydroxy acid dehydrogenase / malonic semialdehyde reductase; Oxidoreductase, short chain dehydrogenase/reductase family, NAD(P)-binding, 3-oxoacyl-[acyl-carrier protein] reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
       0.744
polI
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
  
 0.583
purL
Phosphoribosylformylglycinamide synthetase.
  
  
 0.524
cbp5
Choline-binding protein Cbp5; COG5263, glucan-binding domain (YG repeat).
       0.511
ssbB
Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
  
    0.485
thiI
Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
  
 0.484
pepA
Glutamyl aminopeptidase.
       0.461
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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