STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
smi_0425Conserved hypothetical protein; COG3378, ATPase, phage associated. (534 aa)    
Predicted Functional Partners:
dnaI
Primosome component (helicase loader), primosomal protein DnaI.
  
 
 0.900
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
 
 0.896
smi_0421
ATPase involved in DNA replication initiation; COG0593.
 
     0.803
smi_0424
Conserved hypothetical protein; Pfam09250, Prim-Pol, bifunctional DNA primase/polymerase.
     
 0.799
smi_0423
Conserved hypothetical protein.
       0.781
smi_0420
Conserved hypothetical protein.
       0.779
smi_0422
Helicase.
       0.778
smi_0418
Hypothetical protein.
       0.773
smi_0419
Conserved hypothetical protein.
       0.773
dnaA
DNA biosynthesis, initiation, binding protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
   
 
 0.689
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.