Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
rggDTranscriptional regulators, MutR family; COG1396. (285 aa)    
Predicted Functional Partners:
mutR
Transcriptional regulator; Cd00093, helix-turn-helix XRE-family.
  
  
 
0.911
smi_0484
Transcriptional regulatory protein.
  
  
 0.750
smi_0864
Conserved hypothetical protein; Pfam00293, NUDIX; COG0494, MutT; Belongs to the Nudix hydrolase family.
  
    0.518
smi_0847
Conserved hypothetical protein; COG1247, sortase and related acyltransferases.
   
    0.462
smi_2036
Regulatory protein.
  
    0.455
sagA
General stress protein GSP-781 amidase; Pfam05257, CHAP domain. This domain corresponds to an amidase function.
  
     0.450
smi_0117
Conserved hypothetical protein.
 
   
 0.440
smi_0555
Transcriptional activator, Mga-like regulatory protein; Pfam05043, Mga, M protein trans-acting positive regulator (MGA). Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions.
  
    0.439
smi_0561
Conserved hypothetical protein.
  
     0.434
smi_1101
Conserved hypothetical protein; Pfam06414, Zeta toxin.
   
 
 0.412
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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