Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
recXRegulatory protein RecX; Modulates RecA activity; Belongs to the RecX family. (286 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.940
smi_0488
tRNA methyltransferase, TrmA family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
 
    0.786
smi_0486
Uncharacterized domain/protein associated with RNAses G and E; COG3557; Belongs to the UPF0374 family.
 
     0.776
recO
Conserved hypothetical protein; Involved in DNA repair and RecF pathway recombination.
 
  
 0.748
cinA
Damage inducible protein CinA; COG1058, CinA, predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.
     
 0.744
recJ
Single-stranded DNA-specific exonuclease; COG0608.
 
   
 0.737
purN
5'-phosphoribosylglycinamide transformylase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
     
 0.726
purD
Phosphoribosylglycinamide synthetase; Belongs to the GARS family.
      
 0.724
RadA
DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.698
smi_1150
Histone-like protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
     
 0.691
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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