Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_0560Chromosome segregation helicase, ATPase, AAA family. (423 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 
 0.805
smi_0561
Conserved hypothetical protein.
       0.736
smi_0562
7,8-dihydro-8-oxoguanine-triphosphatase.
       0.736
prmA
Ribosomal protein methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family.
  
  
 0.695
smi_0564
Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.
       0.645
cinA
Damage inducible protein CinA; COG1058, CinA, predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.
     
 0.557
rny
Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay.
 
     0.533
smi_1481
Chorismate binding enzyme para-aminobenzoate synthetase.
  
    0.485
smi_0542
Anthranilate synthase component II (glutamine amido-transferase).
       0.461
parB
Chromosome partitioning protein; parB family, similar to spoOJ; Belongs to the ParB family.
 
  
 0.433
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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