Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_0581Transcriptional regulator, GntR family; HTH motif. (121 aa)    
Predicted Functional Partners:
smi_0580
ABC transporter, ATP binding domain, ABC-type multidrug transport system-unknown substrate; COG1131.
 
    0.968
smi_0579
ABC transporter, permease.
 
  
 0.959
nadR
Bifunctional NadR protein; COG3172, NadR, predicted ATPase/kinase involved in NAD metabolism.
   
    0.686
smi_0585
Nitroreductase family protein, NADPH-flavin oxidoreductase; COG0778; Belongs to the flavin oxidoreductase frp family.
  
    0.565
nrdR
Transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
       0.562
smi_0583
Chromosome replication initiation protein/membrane attachment protein; COG3611.
       0.562
dnaI
Primosome component (helicase loader), primosomal protein DnaI.
       0.562
engA
Phosphoglycerate dehydrogenase-related protein, GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
  
    0.554
smi_0588
Conserved hypothetical protein.
     
 0.491
smi_0256
ABC transporter, ATP-binding protein.
  
    0.471
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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