STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
smi_0583Chromosome replication initiation protein/membrane attachment protein; COG3611. (389 aa)    
Predicted Functional Partners:
dnaI
Primosome component (helicase loader), primosomal protein DnaI.
 
  
 0.881
nrdR
Transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
  
  
 0.874
smi_0585
Nitroreductase family protein, NADPH-flavin oxidoreductase; COG0778; Belongs to the flavin oxidoreductase frp family.
       0.800
engA
Phosphoglycerate dehydrogenase-related protein, GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
       0.773
smi_1287
Conserved hypothetical protein.
  
     0.743
smi_1292
Lysozyme; COG3757, lyzozyme M1 (1,4-beta-N-acetylmuramidase).
  
     0.734
smi_0102
Conserved hypothetical protein; COG3853, toxic anion resistance protein.
  
     0.713
smi_0579
ABC transporter, permease.
 
     0.616
smi_1300
Conserved hypothetical protein; Cd00189, tetratricopeptide repeat domain.
  
     0.577
atpE
Proton-translocating ATPase, F0 sector, subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
  
     0.569
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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