Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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smi_0585Nitroreductase family protein, NADPH-flavin oxidoreductase; COG0778; Belongs to the flavin oxidoreductase frp family. (237 aa)    
Predicted Functional Partners:
nrdR
Transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
       0.865
smi_0583
Chromosome replication initiation protein/membrane attachment protein; COG3611.
       0.865
dnaI
Primosome component (helicase loader), primosomal protein DnaI.
       0.865
engA
Phosphoglycerate dehydrogenase-related protein, GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
       0.847
smi_0257
Conserved hypothetical protein; ABC transporter permease protein.
  
  
 0.596
smi_0581
Transcriptional regulator, GntR family; HTH motif.
  
    0.565
smi_0580
ABC transporter, ATP binding domain, ABC-type multidrug transport system-unknown substrate; COG1131.
  
    0.563
smi_0579
ABC transporter, permease.
  
    0.554
smi_0587
Conserved hypothetical protein.
       0.526
birA
Bifunctional protein, biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
    0.514
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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