Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_0608N-acetylneuraminate lyase. (305 aa)    
Predicted Functional Partners:
smi_0794
N-acetylneuraminate lyase.
  
  
 
0.901
smi_0609
N-acetylmannosamine kinase; transcriptional regulator, ROK family protein.
 
 
 0.898
smi_0606
Conserved hypothetical protein.
 
  
 0.701
smi_0796
Conserved hypothetical protein.
 
  
 0.634
smi_0603
ABC transporter, sugar transporter, sugar binding lipoprotein-N-acetylneuraminate-binding protein.
 
     0.591
smi_0795
Sodium:solute symporter family protein; COG0591, PutP, Na+/proline symporter; pfam00474, SSF; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
 
  
 0.564
smi_0607
Conserved hypothetical protein.
 
     0.536
smi_0792
Transcriptional regulator; COG1737, RpiR.
 
     0.485
smi_1268
Chorismate mutase/prephenate dehydratase; COG1605, Chorismate mutase.
  
    0.468
smi_0612
Phosphosugar-binding transcriptional regulator; Pfam01380, SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
 
     0.466
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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