node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ddL | dltA | smi_0615 | smi_2031 | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | D-alanine:Dcp ligase Dcl; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP-bi [...] | 0.919 |
ddL | dltC | smi_0615 | smi_2029 | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | D-alanyl carrier protein DCP; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.900 |
ddL | murB | smi_0615 | smi_0742 | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.964 |
ddL | murC | smi_0615 | smi_1502 | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.980 |
ddL | murD | smi_0615 | smi_1449 | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | MurD D-glutamic acid adding enzyme; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.847 |
ddL | murF | smi_0615 | smi_0616 | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.997 |
ddL | pbp2B | smi_0615 | smi_0613 | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Penicillin-binding protein 2B. | 0.877 |
ddL | pbp2x | smi_0615 | smi_1767 | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Penicillin-binding protein 2X. | 0.783 |
ddL | recR | smi_0615 | smi_0614 | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Recombination protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.794 |
ddL | smi_0593 | smi_0615 | smi_0593 | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.958 |
dltA | ddL | smi_2031 | smi_0615 | D-alanine:Dcp ligase Dcl; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP-bi [...] | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.919 |
dltA | dltC | smi_2031 | smi_2029 | D-alanine:Dcp ligase Dcl; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP-bi [...] | D-alanyl carrier protein DCP; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.999 |
dltA | smi_0593 | smi_2031 | smi_0593 | D-alanine:Dcp ligase Dcl; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP-bi [...] | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.918 |
dltC | ddL | smi_2029 | smi_0615 | D-alanyl carrier protein DCP; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.900 |
dltC | dltA | smi_2029 | smi_2031 | D-alanyl carrier protein DCP; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | D-alanine:Dcp ligase Dcl; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP-bi [...] | 0.999 |
dltC | smi_0593 | smi_2029 | smi_0593 | D-alanyl carrier protein DCP; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.902 |
murB | ddL | smi_0742 | smi_0615 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | D-ala,D-ala ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.964 |
murB | murC | smi_0742 | smi_1502 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.998 |
murB | murD | smi_0742 | smi_1449 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | MurD D-glutamic acid adding enzyme; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.775 |
murB | murF | smi_0742 | smi_0616 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.878 |