Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
psaCABC transporter membrane-spanning permease-manganese transport. (282 aa)    
Predicted Functional Partners:
psaA
Manganese ABC transporter substrate-binding lipoprotein (Pneumococcal surface adhesin A; Belongs to the bacterial solute-binding protein 9 family.
 
 0.999
smi_0636
Manganese ABC transporter, ATP-binding protein.
 
 0.999
adcA
ABC zinc transporter, metal-binding lipoprotein; Cd01017, metal binding protein AcdA; Belongs to the bacterial solute-binding protein 9 family.
 
  
 0.990
adcC
ABC zinc transporter ATP-binding protein; COG1121, ABC-type Mn/Zn transport, ATPase component.
 
 
 0.919
smi_1143
Metal binding protein, AcdA-family; These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion, signal peptide type I, excreted protein; Belongs to the bacterial solute-binding protein 9 family.
 
  
 0.878
adcB
ABC zinc transporter permease; COG1108, ABC-type Mn2+/Zn2+ transport systems.
 
  
0.528
mntH
Manganese transport protein; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family.
   
  
 0.523
smi_0645
Iron-dependent transcriptional regulator.
 
  
 0.508
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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