Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
smi_0649DNA-binding response regulator. (225 aa)    
Predicted Functional Partners:
smi_0650
Histidine kinase.
 0.999
smi_1075
ABC transporter, membrane-spanning protein; Pfam02687, FtsX, predicted permease.
 
   
 0.923
smi_1076
ABC transporter, ATP-binding protein; COG1136, ABC-type antimicrobial peptide transport system, ATPase component.
 
   
 0.892
smi_0093
Histidine kinase.
 
 
 0.876
smi_1176
Histidine kinase; COG5002, VicK, signal transduction histidine kinase.
 
 
 0.777
smi_0648
Conserved hypothetical protein.
       0.726
smi_1072
Histidine kinase; COG0642, signal transduction histidine kinase.
 
   0.711
smi_1741
Response regulator; COG2197.
  
 
 0.697
ciaH
Sensor protein CiaH histidine kinase.
 
 
 0.638
vicX
Conserved protein VicX; Pfam00753, metallo-beta-lactamase superfamily.
  
  
 0.591
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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