Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_0665Conserved hypothetical protein. (265 aa)    
Predicted Functional Partners:
smi_0664
Bcl-2 family protein; COG2384, SAM-dependent methyltransferase.
  
 0.976
smi_0666
Conserved hypothetical protein; DadA, glycine D-amino acid oxidases.
       0.748
smi_0667
Conserved hypothetical protein; DadA, glycine D-amino acid oxidases.
       0.748
smi_0668
UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
       0.625
pepT
Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.
  
    0.566
smi_0663
P-type ATPase-metal cation transport; COG0474.
       0.563
smi_0669
COG0463, glycosyltransferases involved in cell wall biogenesis.
       0.537
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
    0.474
smi_0739
COG1167, ARO8, transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family).
   
    0.469
nth
Endonuclease III (DNA repair), DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
       0.461
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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