Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_0768COG0438, RfaG; pfam00534, glycosyl transferases group 1. (367 aa)    
Predicted Functional Partners:
smi_0769
Pfam00535, glycosyl transferase group 2.
 
 
 0.994
licD1
Phosphorylcholine transferase LicD1; Pfam04991.
    
 0.918
smi_0771
Conserved hypothetical protein.
     
 0.902
smi_0770
Conserved hypothetical protein.
  
  
 0.876
licD3
Phosphorylcholine transferase LicD3; Pfam04991.
     
 0.828
gtfB
Conserved hypothetical protein; Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. A stabilizing protein that is part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. The GtfA-GtfB complex adds GlcNAc from UDP-GlcNAc to the substrate protein, attaching the first sugar residue. Stabilizes the glycosylation activity of GtfA. Has no N-acetylglucosaminyl transferase activity on its own.
   
 
 0.804
smi_0538
Conserved hypothetical protein; COG2148, WcaJ, sugar transferases involved in lipopolysaccharide synthesis.
 
  
 0.698
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
     
 0.629
smi_0766
Transcriptional regulator; COG1316, LytR.
     
 0.629
pheA
Prephenate dehydratase.
     
 0.618
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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