Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_0795Sodium:solute symporter family protein; COG0591, PutP, Na+/proline symporter; pfam00474, SSF; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (513 aa)    
Predicted Functional Partners:
smi_0794
N-acetylneuraminate lyase.
 
  
 0.853
smi_0792
Transcriptional regulator; COG1737, RpiR.
 
     0.838
smi_0796
Conserved hypothetical protein.
 
     0.777
nanE
N-acetylmannosamine-6-phosphate epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
 
   
 0.683
smi_0797
Oxidoreductase, GFO/IDH/MOCA family; Pfam01408, GFO_IDH_MocA, oxidoreductase family; COG0673, MviM, predicted dehydrogenases and related proteins.
 
   
 0.598
smi_0612
Phosphosugar-binding transcriptional regulator; Pfam01380, SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
 
     0.573
smi_0608
N-acetylneuraminate lyase.
 
  
 0.564
purR
Repressor of purine biosynthetic genes.
   
    0.453
xpt
Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
   
    0.453
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
    0.453
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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