Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_0798COG1940, NagC, transcriptional regulator/sugar kinase; pfam00480, ROK. (296 aa)    
Predicted Functional Partners:
ptsG
PTS glucose-specific enzyme IIABC component.
  
 
 0.912
smi_1615
PTS system; COG1263.
  
 
 0.912
smi_0799
Conserved hypothetical protein.
       0.695
ntpI
V-type H+-ATPase, subunit I; COG1269, NtpI, archaeal/vacuolar-type H+-ATPase subunit I.
       0.695
ntpK
V-type H+-ATPase, subunit K; COG0636, AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K; Belongs to the V-ATPase proteolipid subunit family.
       0.658
ntpE
V-type H+-ATPase, subunit E.
       0.565
smi_1614
Transcriptional regulator/sugar kinase; COG1940.
  
     0.556
smi_0796
Conserved hypothetical protein.
 
    0.475
smi_0797
Oxidoreductase, GFO/IDH/MOCA family; Pfam01408, GFO_IDH_MocA, oxidoreductase family; COG0673, MviM, predicted dehydrogenases and related proteins.
       0.471
ntpC
V-type H+-ATPase, subunit C; COG1527, NtpC, Archaeal/vacuolar-type H+-ATPase subunit C.
  
    0.437
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
Server load: low (26%) [HD]