Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gdhACOG0334, GdhA, glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (448 aa)    
Predicted Functional Partners:
glnA
Glutamine synthetase type 1.
  
 
 0.977
aspC2
Aspartate aminotransferase.
  
 
 0.910
murI
Glutamate racemase, COG0796; Provides the (R)-glutamate required for cell wall biosynthesis.
  
 
 0.837
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
     
 0.820
smi_0880
Conserved hypothetical protein.
   
 0.811
smi_0593
Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
    
 0.807
pgsA
Phosphatidylglycerophosphate synthase; COG0558, PgsA; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
 0.710
pyrD2
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate.
     
 0.701
zwf
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
   
 
 0.675
glnR
Transcriptional repressor of the glutamine synthetase gene.
      
 0.595
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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