Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rlmNConserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (361 aa)    
Predicted Functional Partners:
smi_0820
VanZ-related protein; COG4767, VanZ, glycopeptide antibiotics resistance protein; pfam04892, VanZ like family.
       0.865
smi_1624
rRNA-specific 5-methylcytidine transferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.848
smi_0818
Conserved hypothetical protein.
       0.830
tsf
Elongation factor TS; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.
 
  
 0.752
smi_0821
ABC transporter, ATP-binding protein; COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains.
       0.718
thrA
Homoserine dehydrogenase.
     
 0.695
smi_1354
Pyridoxal-phosphate dependent aminotransferase; COG1104, cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
  
  
 0.653
smi_0731
Conserved hypothetical protein; COG0144, sun, tRNA and rRNA cytosine-C5-methylases [.
  
  
 0.640
smi_0720
Coproporphyrinogen III oxidase, oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
   
 0.597
smi_1622
Serine/threonine protein kinase; COG2815.
  
  
 0.573
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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