Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_0827Conserved hypothetical protein. (110 aa)    
Predicted Functional Partners:
smi_0826
Conserved hypothetical protein; COG1837, predicted RNA-binding protein (contains KH domain); Belongs to the UPF0109 family.
  
    0.783
rpsP
30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.
       0.709
smi_0828
Conserved hypothetical protein; COG0596, MhpC, predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); pfam00561, Abhydrolase_1, alpha/beta hydrolase fold.
       0.528
rimM
16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family.
       0.494
trmD
tRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.
       0.494
birA
Bifunctional protein, biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.488
smi_0831
Conserved hypothetical protein; COG1328, NrdD, oxygen-sensitive ribonucleoside-triphosphate reductase; pfam03477, ATP-cone, ATP cone domain.
       0.483
smi_0531
Metal-dependent membrane protease, CAAX amino terminal protease family protein; COG1266.
 
     0.447
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
       0.447
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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