Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gorGlutathione disulfide reductase. (448 aa)    
Predicted Functional Partners:
gpo
Gluthatione peroxidase; COG0386; Belongs to the glutathione peroxidase family.
  
 0.933
tpx
Thioredoxin-linked thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily.
  
  
 0.686
acrA
Conserved hypothetical protein; COG0845, efflux transporter.
       0.667
salX
ABC transporter, ATP-binding protein; COG1136, ABC-type antimicrobial peptide transport system, ATPase component.
       0.667
salY
ABC transporter, permease; COG0577, ABC-type antimicrobial peptide transport system, permease component.
       0.667
smi_0404
Conserved hypothetical protein; COG0526: thiol-disulfide isomerase and thioredoxins.
  
 0.623
smi_1553
Thioredoxin reductase; COG0492.
  
 
 0.619
guaB
Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.609
smi_0573
Thioredoxin; Belongs to the thioredoxin family.
  
 
 0.561
prsA
Phosphoribosylpyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
   
 0.489
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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