Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
acrAConserved hypothetical protein; COG0845, efflux transporter. (401 aa)    
Predicted Functional Partners:
salY
ABC transporter, permease; COG0577, ABC-type antimicrobial peptide transport system, permease component.
 
 
 0.998
salX
ABC transporter, ATP-binding protein; COG1136, ABC-type antimicrobial peptide transport system, ATPase component.
 
 
 0.987
metS
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
   
   0.690
smi_1970
ABC transporter ATP-binding protein; COG1136, antimicrobial peptide transport system, ATPase component.
 
 
 0.688
gor
Glutathione disulfide reductase.
       0.667
smi_1450
ABC transporter, ATP-binding protein.
  
 
 0.622
smi_0826
Conserved hypothetical protein; COG1837, predicted RNA-binding protein (contains KH domain); Belongs to the UPF0109 family.
     
 0.566
smi_1075
ABC transporter, membrane-spanning protein; Pfam02687, FtsX, predicted permease.
  
 
 0.557
smi_1459
ABC transporter, permease; ABC-type antimicrobial peptide transport system.
  
 
 0.557
crcB2
CrcB protein, paralog 2; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.
      
 0.521
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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