smi_0859 protein (Streptococcus mitis) - STRING interaction network

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Score

smi_0859

Phosphatase; COG0546, Gph, predicted phosphatase. (190 aa)

Predicted Functional Partners:

gyrB

0.845

ezrA

0.726

smi_1186

0.546

tnpA-22

0.513

smi_1292

0.455

smi_0844

0.442

rodA

0.434

glnR

0.431

serB

0.409

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ezrA	gyrB	smi_0861	smi_0860	Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.	DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.742
ezrA	rodA	smi_0861	smi_0856	Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.	Pfam01098, FTSW_RODA_SPOVE, cell cycle protein; Belongs to the SEDS family.	0.868
ezrA	serB	smi_0861	smi_1162	Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.	Phosphoserine phosphatase.	0.515
ezrA	smi_0859	smi_0861	smi_0859	Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.	Phosphatase; COG0546, Gph, predicted phosphatase.	0.726
ezrA	smi_1186	smi_0861	smi_1186	Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.	Conserved hypothetical protein.	0.418
glnR	smi_0859	smi_0348	smi_0859	Transcriptional repressor of the glutamine synthetase gene.	Phosphatase; COG0546, Gph, predicted phosphatase.	0.431
gyrB	ezrA	smi_0860	smi_0861	DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.	0.742
gyrB	rodA	smi_0860	smi_0856	DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Pfam01098, FTSW_RODA_SPOVE, cell cycle protein; Belongs to the SEDS family.	0.461
gyrB	serB	smi_0860	smi_1162	DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Phosphoserine phosphatase.	0.469
gyrB	smi_0859	smi_0860	smi_0859	DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Phosphatase; COG0546, Gph, predicted phosphatase.	0.845
gyrB	tnpA-22	smi_0860	smi_0858	DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Transposase, ISSmi1; COG2826, IS30 family.	0.491
rodA	ezrA	smi_0856	smi_0861	Pfam01098, FTSW_RODA_SPOVE, cell cycle protein; Belongs to the SEDS family.	Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.	0.868
rodA	gyrB	smi_0856	smi_0860	Pfam01098, FTSW_RODA_SPOVE, cell cycle protein; Belongs to the SEDS family.	DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.461
rodA	smi_0859	smi_0856	smi_0859	Pfam01098, FTSW_RODA_SPOVE, cell cycle protein; Belongs to the SEDS family.	Phosphatase; COG0546, Gph, predicted phosphatase.	0.434
serB	ezrA	smi_1162	smi_0861	Phosphoserine phosphatase.	Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.	0.515
serB	gyrB	smi_1162	smi_0860	Phosphoserine phosphatase.	DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.469
serB	smi_0859	smi_1162	smi_0859	Phosphoserine phosphatase.	Phosphatase; COG0546, Gph, predicted phosphatase.	0.409
smi_0844	smi_0859	smi_0844	smi_0859	Conserved hypothetical protein.	Phosphatase; COG0546, Gph, predicted phosphatase.	0.442
smi_0844	smi_1186	smi_0844	smi_1186	Conserved hypothetical protein.	Conserved hypothetical protein.	0.566
smi_0859	ezrA	smi_0859	smi_0861	Phosphatase; COG0546, Gph, predicted phosphatase.	Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.	0.726