Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_0877Voltage-gated chloride channel family protein, (ClC) family protein; COG0038. (427 aa)    
Predicted Functional Partners:
pnp
Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
   
   0.869
deoB
Phosphopentomutase DeoB; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
       0.865
smi_0875
Conserved hypothetical protein.
       0.865
rpiA
Ribose-5-phosphate epimerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
       0.823
smi_0878
COG0518, GuaA, GMP synthase - glutamine amidotransferase domain.
       0.676
deoD
Purine-nucleoside phosphorylase DeoD; COG0813.
       0.579
smi_1722
Na+/alanine symporter; COG1115.
   
    0.495
smi_0872
Conserved hypothetical protein.
       0.430
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
Server load: low (22%) [HD]