Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_0898Hypothetical protein. (214 aa)    
Predicted Functional Partners:
parE
DNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily.
   
   0.690
smi_0900
Hypothetical protein.
       0.664
smi_0899
Hypothetical protein.
       0.658
smi_1251
Helicase; Cd00079.
       0.528
plsY
Conserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
       0.499
smi_1604
Type I restriction-modification system, helicase subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification.
  
   0.433
smi_2016
COG2865, predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen.
 
     0.428
smi_1247
Type III restriction endonuclease; Pfam04851.
       0.406
smi_1249
Adenine-specific DNA methylase; COG2189.
       0.406
smi_1250
Hypothetical protein.
       0.406
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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