Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pbp3D-alanyl-D-alanine carboxypeptidase, penicillin-binding protein 3; Belongs to the peptidase S11 family. (413 aa)    
Predicted Functional Partners:
pbp1a
Penicillin-binding protein 1a.
  
 
 0.970
pbp2B
Penicillin-binding protein 2B.
  
 
 0.968
pbp2x
Penicillin-binding protein 2X.
  
 
 0.968
pbp2a
Penicillin-binding protein 2A.
  
 
 0.948
vanYb
Carboxypeptidase; Penicillin-insensitive metallo-DD-carboxypeptidase.
     
 0.910
smi_0921
Membrane protein; COG0628, PerM, predicted permease.
       0.648
rlmH
Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.
  
  
 0.559
tig
FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
  
    0.463
smi_1622
Serine/threonine protein kinase; COG2815.
   
  
 0.443
guaB
Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
    0.409
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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