smi_0942 protein (Streptococcus mitis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

smi_0942

Site-specific DNA methylase; COG0270, Dcm. (351 aa)

Predicted Functional Partners:

metK

0.904

smi_0778

0.902

pfs

0.900

smi_0943

0.856

smi_0944

0.828

smi_0945

0.693

smi_0946

0.693

smi_0947

0.693

dpnIIB

0.548

smi_0940

0.433

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
dpnIIB	smi_0942	smi_0524	smi_0942	DNA adenine methyltransferase, (adenine-specific methyltransferase DpnIIB); Belongs to the N(4)/N(6)-methyltransferase family.	Site-specific DNA methylase; COG0270, Dcm.	0.548
metK	pfs	smi_1400	smi_1288	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.	0.844
metK	smi_0942	smi_1400	smi_0942	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	Site-specific DNA methylase; COG0270, Dcm.	0.904
metK	smi_0944	smi_1400	smi_0944	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	Site-specific DNA methylase; COG0270, Dcm.	0.904
pfs	metK	smi_1288	smi_1400	5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.844
pfs	smi_0778	smi_1288	smi_0778	5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.	Atz/Trz family protein, N-terminal truncation.	0.910
pfs	smi_0942	smi_1288	smi_0942	5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.	Site-specific DNA methylase; COG0270, Dcm.	0.900
pfs	smi_0944	smi_1288	smi_0944	5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.	Site-specific DNA methylase; COG0270, Dcm.	0.900
smi_0778	pfs	smi_0778	smi_1288	Atz/Trz family protein, N-terminal truncation.	5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.	0.910
smi_0778	smi_0942	smi_0778	smi_0942	Atz/Trz family protein, N-terminal truncation.	Site-specific DNA methylase; COG0270, Dcm.	0.902
smi_0778	smi_0944	smi_0778	smi_0944	Atz/Trz family protein, N-terminal truncation.	Site-specific DNA methylase; COG0270, Dcm.	0.902
smi_0940	smi_0942	smi_0940	smi_0942	Conserved hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.	Site-specific DNA methylase; COG0270, Dcm.	0.433
smi_0940	smi_0943	smi_0940	smi_0943	Conserved hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.	Conserved hypothetical protein.	0.433
smi_0940	smi_0944	smi_0940	smi_0944	Conserved hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.	Site-specific DNA methylase; COG0270, Dcm.	0.433
smi_0942	dpnIIB	smi_0942	smi_0524	Site-specific DNA methylase; COG0270, Dcm.	DNA adenine methyltransferase, (adenine-specific methyltransferase DpnIIB); Belongs to the N(4)/N(6)-methyltransferase family.	0.548
smi_0942	metK	smi_0942	smi_1400	Site-specific DNA methylase; COG0270, Dcm.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.904
smi_0942	pfs	smi_0942	smi_1288	Site-specific DNA methylase; COG0270, Dcm.	5'-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.	0.900
smi_0942	smi_0778	smi_0942	smi_0778	Site-specific DNA methylase; COG0270, Dcm.	Atz/Trz family protein, N-terminal truncation.	0.902
smi_0942	smi_0940	smi_0942	smi_0940	Site-specific DNA methylase; COG0270, Dcm.	Conserved hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.	0.433
smi_0942	smi_0943	smi_0942	smi_0943	Site-specific DNA methylase; COG0270, Dcm.	Conserved hypothetical protein.	0.856