| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ilvA | sdaA | smi_1822 | smi_1980 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-serine dehydratase, alpha subunit; Pfam03313; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.917 |
| ilvA | sdaB | smi_1822 | smi_1979 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-serine dehydratase, beta subunit; Pfam 03315; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.934 |
| ilvA | smi_0962 | smi_1822 | smi_0962 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | COG0346, GloA, lactoylglutathione lyase and related lyases. | 0.803 |
| ilvA | trpA | smi_1822 | smi_0547 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.911 |
| ilvA | trpB | smi_1822 | smi_0546 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.927 |
| infC | rplT | smi_0959 | smi_0961 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.993 |
| infC | rpmI | smi_0959 | smi_0960 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. | 0.992 |
| infC | smi_0962 | smi_0959 | smi_0962 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | COG0346, GloA, lactoylglutathione lyase and related lyases. | 0.604 |
| rplT | infC | smi_0961 | smi_0959 | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 0.993 |
| rplT | rpmI | smi_0961 | smi_0960 | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. | 0.999 |
| rplT | smi_0962 | smi_0961 | smi_0962 | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | COG0346, GloA, lactoylglutathione lyase and related lyases. | 0.767 |
| rpmI | infC | smi_0960 | smi_0959 | 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 0.992 |
| rpmI | rplT | smi_0960 | smi_0961 | 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.999 |
| rpmI | smi_0962 | smi_0960 | smi_0962 | 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. | COG0346, GloA, lactoylglutathione lyase and related lyases. | 0.683 |
| sdaA | ilvA | smi_1980 | smi_1822 | L-serine dehydratase, alpha subunit; Pfam03313; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.917 |
| sdaA | sdaB | smi_1980 | smi_1979 | L-serine dehydratase, alpha subunit; Pfam03313; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. | L-serine dehydratase, beta subunit; Pfam 03315; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.999 |
| sdaA | smi_0962 | smi_1980 | smi_0962 | L-serine dehydratase, alpha subunit; Pfam03313; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. | COG0346, GloA, lactoylglutathione lyase and related lyases. | 0.800 |
| sdaA | trpA | smi_1980 | smi_0547 | L-serine dehydratase, alpha subunit; Pfam03313; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.951 |
| sdaA | trpB | smi_1980 | smi_0546 | L-serine dehydratase, alpha subunit; Pfam03313; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| sdaB | ilvA | smi_1979 | smi_1822 | L-serine dehydratase, beta subunit; Pfam 03315; COG1760; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.934 |
